Wash hands with a non-medicated soap (contains no Benzoyl Peroxide). Cleanse and dry face thoroughly before use. Using fingertips apply evenly to affected areas. Use both morning and night or as directed by a physician. If dryness or peeling occurs, reduce application to once a day or every other day. Fair-skinned individuals should begin with one application. For more severe cases, and/or if substantial improvement is not apparent within 3 to 4 weeks, consult a health care practitioner.